Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Research is still not conclusive as to how PCSK9 inhibitors will affect cardiovascular events over time. Talk to a doctor about how statins work in the long term and how they may affect you. PCSK9 inhibitors may provide another option for people with LDL cholesterol who are at high risk of heart disease but can’t tolerate statins. Most people can take statins, but side effects like digestive problems and muscle pain may make it difficult for some people to tolerate. PCSK9 inhibitors require injections every 2 to 4 weeks in a medical facility and may be more costly since there aren’t generic versions of these medications. help your body reabsorb built-up cholesterol deposits from your arteriesĪffordable brand name and generic statins are available as prescriptions.block HMG-CoA reductase, an enzyme that your liver uses to make cholesterol.Statins taken as oral tablets or capsule can: PCSK9 are delivered as injections that directly affect the activity of the PCSK9 gene. This blocks the gene from reducing LDL receptors that help lower LDL cholesterol in the body.Ī 2015 clinical trial also showed success in lowering LDL cholesterol - only 1.7 percent of people studied experienced some type of heart-related event during the trial’s 78-week period.īoth PCSK9 inhibitors and statins are often used to help lower LDL cholesterol, especially when statins or lifestyle changes haven’t helped lower LDL cholesterol.Ī 2017 review in the World Journal of Cardiology suggested that using PCSK9 inhibitors could help lower LDL cholesterol in the blood by 50 percent or more just by using statins. Just like evolocumab in Repatha, the substance alirocumab used in Praluent is a monoclonal antibody protein that attaches to the PCSK9 gene. Alirocumab (Praluent)Īlirocumab ( Praluent) is another commonly used PCSK9 inhibitor that was approved by the FDA in July 2015. In the following year, just under 1 percent of people taking evolocumab had a heart-related event as compared to over 2 percent of people who weren’t taking the medication. This action allows more receptors to lower LDL cholesterol in the blood without the interference of the PCSK9 gene.Ī 2015 clinical trial found that people taking evolocumab for 1 year reduced their LDL cholesterol by about 60 percent compared to those who didn’t take it. In this case, that means the evolocumab protein attaches to and blocks the PCSK9 gene from reducing LDL receptors. The substance evolocumab used in Repatha is known as a monoclonal antibody protein. One common PCSK9 inhibitor called evolocumab (Repatha) was approved by the Food and Drug Administration (FDA) in 2015. Here are common PCSK9 inhibitors and what the research says about their effectiveness. PCSK9 inhibitors suppress the PCSK9 enzyme expressed by the gene.
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